Anti-CD79B antibody (130-229 aa) [SRM5080] (STJ11106860)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal CD79B (130-229 aa) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5080 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:20000IHC-P:1:500-1:1000IF/ICC:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
Target Information
| Gene Symbol | CD79B |
| Gene ID | 974 |
| Uniprot ID | CD79B_HUMAN |
| Immunogen Region | 130-229 aa |
| Immunogen Sequence | SEVYQGCGTELRVMGFSTLA QLKQRNTLKDGIIMIQTLLI ILFIIVPIFLLLDKDDSKAG MEEDHTYEGLDIDQTATYED IVTLRTGEVKWSVGEHPGQE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 130-229 of human CD79B Rabbit PolymAb® (NP_000617.1). |
Additional Info
| Tissue Specificity | B-cells. |
| Post Translational Modifications | Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. |
| Function | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. |
| Protein Name | B-Cell Antigen Receptor Complex-Associated Protein Beta ChainB-Cell-Specific Glycoprotein B29Ig-BetaImmunoglobulin-Associated B29 ProteinCd Antigen Cd79b |
| Database Links | Reactome: R-HSA-5690714Reactome: R-HSA-9679191Reactome: R-HSA-983695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinFollowing Antigen BindingThe Bcr Has Been Shown To Translocate From Detergent-Soluble Regions Of The Cell Membrane To Lipid Rafts Although Signal Transduction Through The Complex Can Also Occur Outside Lipid Rafts |
| Alternative Antibody Names | Anti-B-Cell Antigen Receptor Complex-Associated Protein Beta Chain antibodyAnti-B-Cell-Specific Glycoprotein B29 antibodyAnti-Ig-Beta antibodyAnti-Immunoglobulin-Associated B29 Protein antibodyAnti-Cd Antigen Cd79b antibodyAnti-CD79B antibodyAnti-B29 antibodyAnti-IGB antibody |
Information sourced from Uniprot.org