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![Anti-CD74 antibody [SM4946] (STJA0004946)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180017/403229/STJA0004946_5__97872.1738950319.png?c=1 "Anti-CD74 antibody [SM4946] (STJA0004946)")
![Anti-CD74 antibody [SM4946] (STJA0004946)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180017/403230/STJA0004946_6__92728.1738950319.png?c=1 "Anti-CD74 antibody [SM4946] (STJA0004946)")
| Host: | Mouse |
| Applications: | WB/IHC/IF |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-CD74 for use in WB, IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | SM4946 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB (H) 1:500-1:1000IHC/IF (H) 1:500-1:1000 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | CD74 |
| Gene ID: | 972 |
| Uniprot ID: | HG2A_HUMAN |
| Immunogen: | Recombinant human CD74 protein expressed in HEK293 cells |
| Post Translational Modifications | O-glycosylated with core 1 or possibly core 8 glycans. Contains chondroitin sulfate. |
| Function | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. Isoform p41: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform. |
| Protein Name | Hla Class Ii Histocompatibility Antigen Gamma ChainHla-Dr Antigens-Associated Invariant ChainIa Antigen-Associated Invariant ChainIiCd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain PeptideClip |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-2132295 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinEndoplasmic Reticulum MembraneGolgi ApparatusTrans-Golgi NetworkEndosomeLysosomeSecretedTransits Through A Number Of Intracellular Compartments In The Endocytic PathwayIt Can Either Undergo Proteolysis Or Reach The Cell MembraneIsoform P41: Late Endosome |
| Alternative Antibody Names | Anti-Hla Class Ii Histocompatibility Antigen Gamma Chain antibodyAnti-Hla-Dr Antigens-Associated Invariant Chain antibodyAnti-Ia Antigen-Associated Invariant Chain antibodyAnti-Ii antibodyAnti-Cd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain Peptide antibodyAnti-Clip antibodyAnti-CD74 antibodyAnti-DHLAG antibody |
Information sourced from Uniprot.org
