| Host: |
Mouse |
| Applications: |
FC/IHC-F/IF/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-CD74 is suitable for use in Flow Cytometry, Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
EBS-O-041 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1K |
| Formulation: |
PBS with 0.02% sodium azide |
| Concentration: |
100 ug/mL |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
CD74 |
| Gene ID: |
972 |
| Uniprot ID: |
HG2A_HUMAN |
| Immunogen: |
B lymphoblastoid cell line HFB1. |
| Tissue Specificity | Detected in urine (at protein level). Isoform p41: In B cells, represents 10% of total CD74 expression. Isoform p33: In B cells, represents 70% of total CD74 expression. |
| Post Translational Modifications | O-glycosylated with core 1 or possibly core 8 glycans. Contains chondroitin sulfate. |
| Function | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. Isoform p41: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform. |
| Protein Name | Hla Class Ii Histocompatibility Antigen Gamma ChainHla-Dr Antigens-Associated Invariant ChainIa Antigen-Associated Invariant ChainIiCd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain PeptideClip |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-2132295 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinEndoplasmic Reticulum MembraneGolgi ApparatusTrans-Golgi NetworkEndosomeLysosomeSecretedTransits Through A Number Of Intracellular Compartments In The Endocytic PathwayIt Can Either Undergo Proteolysis Or Reach The Cell MembraneIsoform P41: Late Endosome |
| Alternative Antibody Names | Anti-Hla Class Ii Histocompatibility Antigen Gamma Chain antibodyAnti-Hla-Dr Antigens-Associated Invariant Chain antibodyAnti-Ia Antigen-Associated Invariant Chain antibodyAnti-Ii antibodyAnti-Cd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain Peptide antibodyAnti-Clip antibodyAnti-CD74 antibodyAnti-DHLAG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
