| Tissue Specificity | Pre-B-cells and B-cells but not terminally differentiated plasma cells. |
| Post Translational Modifications | Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1. |
| Function | Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis. |
| Protein Name | B-Cell Differentiation Antigen Cd72Lyb-2Cd Antigen Cd72 |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-B-Cell Differentiation Antigen Cd72 antibodyAnti-Lyb-2 antibodyAnti-Cd Antigen Cd72 antibodyAnti-CD72 antibody |
Information sourced from Uniprot.org
