| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-CD70 antigen (150-193 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200 ELISA 1:10000-20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD70 |
| Gene ID: | 970 |
| Uniprot ID: | CD70_HUMAN |
| Immunogen Region: | 150-193 aa |
| Specificity: | The antibody detects endogenous CD70 |
| Immunogen: | Synthetic peptide from the human protein at the amino acid range 150-193 |
| Function | Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. |
| Protein Name | Cd70 Antigen Cd27 Ligand Cd27-L Tumor Necrosis Factor Ligand Superfamily Member 7 Cd Antigen Cd70 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Cd70 Antigen antibody Anti-Cd27 Ligand antibody Anti-Cd27-L antibody Anti-Tumor Necrosis Factor Ligand Superfamily Member 7 antibody Anti-Cd Antigen Cd70 antibody Anti-CD70 antibody Anti-CD27L antibody Anti-CD27LG antibody Anti-TNFSF7 antibody |
Information sourced from Uniprot.org