| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:2500-1:10000IHC-P:1:200-1:800IF/ICC:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CD69 |
| Gene ID: |
969 |
| Uniprot ID: |
CD69_HUMAN |
| Immunogen Region: |
62-199 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 62-199 of human CD69 (NP_001772.1). |
| Immunogen Sequence: |
SVGQYNCPGQYTFSMPSDSH VSSCSEDWVGYQRKCYFIST VKRSWTSAQNACSEHGATLA VIDSEKDMNFLKRYAGREEH WVGLKKEPGHPWKWSNGKEF NNWFNVTGSDKCVFLKNTEV SSMECEKNLYWICNKPYK |
| Tissue Specificity | Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. |
| Post Translational Modifications | Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes. |
| Function | Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types. Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells. Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage. Acts also via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells. Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT. Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P. aeruginosa infection. Mechanistically, specifically recognizes P. aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion. In eosinophils, induces IL-10 production through the ERK1/2 pathway. Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor. |
| Protein Name | Early Activation Antigen Cd69Activation Inducer MoleculeAimBl-Ac/P26C-Type Lectin Domain Family 2 Member CEa1Early T-Cell Activation Antigen P60Gp32/28Leukocyte Surface Antigen Leu-23Mlr-3Cd Antigen Cd69 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Early Activation Antigen Cd69 antibodyAnti-Activation Inducer Molecule antibodyAnti-Aim antibodyAnti-Bl-Ac/P26 antibodyAnti-C-Type Lectin Domain Family 2 Member C antibodyAnti-Ea1 antibodyAnti-Early T-Cell Activation Antigen P60 antibodyAnti-Gp32/28 antibodyAnti-Leukocyte Surface Antigen Leu-23 antibodyAnti-Mlr-3 antibodyAnti-Cd Antigen Cd69 antibodyAnti-CD69 antibodyAnti-CLEC2C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
