Anti-CD68 antibody [514H12] (STJ16100849)

SKU:
STJ16100849-1

£1,240.50
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Host: Mouse
Applications: IHC-P/IHC-F/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD68 is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: 514H12
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: PBS with 0.09% sodium azide
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CD68
Gene ID: 968
Uniprot ID: CD68_HUMAN
Immunogen: Fusion protein corresponding to external domain of human CD68.
Tissue Specificity Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
Post Translational Modifications N- and O-glycosylated.
Function Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Protein Name Macrosialin
Gp110
Cd Antigen Cd68
Database Links Reactome: R-HSA-6798695
Cellular Localisation Isoform Short: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform Long: Endosome Membrane
Lysosome Membrane
Alternative Antibody Names Anti-Macrosialin antibody
Anti-Gp110 antibody
Anti-Cd Antigen Cd68 antibody
Anti-CD68 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance