| Tissue Specificity | Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. |
| Function | Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3). |
| Protein Name | P-SelectinCd62 Antigen-Like Family Member PGranule Membrane Protein 140Gmp-140Leukocyte-Endothelial Cell Adhesion Molecule 3Lecam3Platelet Activation Dependent Granule-External Membrane ProteinPadgemCd Antigen Cd62p |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-P-Selectin antibodyAnti-Cd62 Antigen-Like Family Member P antibodyAnti-Granule Membrane Protein 140 antibodyAnti-Gmp-140 antibodyAnti-Leukocyte-Endothelial Cell Adhesion Molecule 3 antibodyAnti-Lecam3 antibodyAnti-Platelet Activation Dependent Granule-External Membrane Protein antibodyAnti-Padgem antibodyAnti-Cd Antigen Cd62p antibodyAnti-SELP antibodyAnti-GMRP antibodyAnti-GRMP antibody |
Information sourced from Uniprot.org
