Anti-CD6 antibody [EBS-CD-005] (STJ16101118)

SKU:
STJ16101118

£274.50 - £1,323.50
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Host: Mouse
Applications: FC/IF/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD6 is suitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: EBS-CD-005
Conjugation: Unconjugated
Isotype: IgG3k
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunofluorescence (0, 5-1, 0 µg/ml). Immunohistology (1-2 µg/ml for 30 min at RT; an appropriate antigen retrieval method for staining of formalin-fixed tissue has not been established to date)
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol: CD6
Gene ID: 923
Uniprot ID: CD6_HUMAN
Immunogen: A BALB/c mouse was immunized with cells of a human CD8+ human CTL clone. Fusion partner: SP2/0.
Tissue Specificity Detected on thymocytes. Detected on peripheral blood T-cells. Detected on natural killer (NK) cells. Soluble CD6 is detected in blood serum (at protein level). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes. Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
Post Translational Modifications After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Glycosylated.
Function Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule.promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
Protein Name T-Cell Differentiation Antigen Cd6
T12
Tp120
Cd Antigen Cd6 Cleaved Into - Soluble Cd6
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Detected At The Immunological Synapse
I
E
At The Contact Zone Between Antigen-Presenting Dendritic Cells And T-Cells
Colocalizes With The Tcr/Cd3 Complex At The Immunological Synapse
Soluble Cd6: Secreted
The Origins Of The Secreted Form Are Not Clear
But It Might Be Created By Proteolytic Shedding Of The Ectodomain
Alternative Antibody Names Anti-T-Cell Differentiation Antigen Cd6 antibody
Anti-T12 antibody
Anti-Tp120 antibody
Anti-Cd Antigen Cd6 Cleaved Into - Soluble Cd6 antibody
Anti-CD6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance