• Immunohistochemical analysis of paraffin-embedded human-tonsils, antibody was diluted at 1:100
  • Western blot analysis of 293 cells using CD6 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-CD6 antibody (361-410 aa) (STJ97272)

SKU:
STJ97272

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-T-cell differentiation antigen CD6 (361-410 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD6
Gene ID: 923
Uniprot ID: CD6_HUMAN
Immunogen Region: 361-410 aa
Specificity: CD6 Polyclonal Antibody detects endogenous levels of CD6 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human CD6 at the amino acid range 361-410
Post Translational Modifications After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Glycosylated.
Function Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule.promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
Protein Name T-Cell Differentiation Antigen Cd6
T12
Tp120
Cd Antigen Cd6 Cleaved Into - Soluble Cd6
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Detected At The Immunological Synapse
I
E
At The Contact Zone Between Antigen-Presenting Dendritic Cells And T-Cells
Colocalizes With The Tcr/Cd3 Complex At The Immunological Synapse
Soluble Cd6: Secreted
The Origins Of The Secreted Form Are Not Clear
But It Might Be Created By Proteolytic Shedding Of The Ectodomain
Alternative Antibody Names Anti-T-Cell Differentiation Antigen Cd6 antibody
Anti-T12 antibody
Anti-Tp120 antibody
Anti-Cd Antigen Cd6 Cleaved Into - Soluble Cd6 antibody
Anti-CD6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance