| Host: |
Mouse |
| Applications: |
FC/IP/IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-CD59 is suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
MEM-43 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a |
| Formulation: |
Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Concentration: |
1 mg/mL |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
CD59 |
| Gene ID: |
966 |
| Uniprot ID: |
CD59_HUMAN |
| Immunogen: |
Thymocytes and T lymphocytes |
| Post Translational Modifications | N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine. Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants. Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes. |
| Function | Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. |
| Protein Name | Cd59 Glycoprotein1f5 Antigen20 Kda Homologous Restriction FactorHrf-20Hrf20Mac-Inhibitory ProteinMac-IpMem43 AntigenMembrane Attack Complex Inhibition FactorMacifMembrane Inhibitor Of Reactive LysisMirlProtectinCd Antigen Cd59 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-977606 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedSoluble Form Found In A Number Of Tissues |
| Alternative Antibody Names | Anti-Cd59 Glycoprotein antibodyAnti-1f5 Antigen antibodyAnti-20 Kda Homologous Restriction Factor antibodyAnti-Hrf-20 antibodyAnti-Hrf20 antibodyAnti-Mac-Inhibitory Protein antibodyAnti-Mac-Ip antibodyAnti-Mem43 Antigen antibodyAnti-Membrane Attack Complex Inhibition Factor antibodyAnti-Macif antibodyAnti-Membrane Inhibitor Of Reactive Lysis antibodyAnti-Mirl antibodyAnti-Protectin antibodyAnti-Cd Antigen Cd59 antibodyAnti-CD59 antibodyAnti-MIC11 antibodyAnti-MIN1 antibodyAnti-MIN2 antibodyAnti-MIN3 antibodyAnti-MSK21 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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