| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD58 |
| Gene ID: | 965 |
| Uniprot ID: | LFA3_HUMAN |
| Immunogen Region: | 40-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-220 of human CD58 (NP_001770.1). |
| Immunogen Sequence: | NVTFHVPSNVPLKEVLWKKQ KDKVAELENSEFRAFSSFKN RVYLDTVSGSLTIYNLTSSD EDEYEMESPNITDTMKFFLY VLESLPSPTLTCALTNGSIE VQCMIPEHYNSHRGLIMYSW DCPMEQCKRNSTSIYFKMEN DLPQKIQCTLSNPLFNTTSS IILTTCIPSSGHSRHRYALI P |
| Function | Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. |
| Protein Name | Lymphocyte Function-Associated Antigen 3Ag3Surface Glycoprotein Lfa-3Cd Antigen Cd58 |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Lymphocyte Function-Associated Antigen 3 antibodyAnti-Ag3 antibodyAnti-Surface Glycoprotein Lfa-3 antibodyAnti-Cd Antigen Cd58 antibodyAnti-CD58 antibodyAnti-LFA3 antibody |
Information sourced from Uniprot.org