| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | HNK-1 |
| Conjugation: | AF488 |
| Isotype: | IgMk |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Concentration: | 5 Mu L/Test |
| Storage Instruction: | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | B3GAT1 |
| Gene ID: | 27087 |
| Uniprot ID: | B3GA1_HUMAN |
| Tissue Specificity | Mainly expressed in the brain. |
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. |
| Function | Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. |
| Protein Name | Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 1Beta-1 -3-Glucuronyltransferase 1Glucuronosyltransferase PGlcat-PUdp-Glcua -Glycoprotein Beta-1 -3-GlucuronyltransferaseGlcuat-P |
| Database Links | Reactome: R-HSA-1971475 |
| Cellular Localisation | Isoform 1: Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecretedIsoform 2: Golgi Apparatus MembraneEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 1 antibodyAnti-Beta-1 -3-Glucuronyltransferase 1 antibodyAnti-Glucuronosyltransferase P antibodyAnti-Glcat-P antibodyAnti-Udp-Glcua -Glycoprotein Beta-1 -3-Glucuronyltransferase antibodyAnti-Glcuat-P antibodyAnti-B3GAT1 antibodyAnti-GLCATP antibody |
Information sourced from Uniprot.org
