| Tissue Specificity | Brain, secretory epithelia, skeletal muscle, liver, testes, thymus, spleen and lymph node. |
| Function | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. |
| Protein Name | Complement Decay-Accelerating Factor - Gpi-AnchoredDaf-GpiCd Antigen Cd55 |
| Database Links | Reactome: R-MMU-373080Reactome: -MMU-6798695Reactome: -MMU-6807878Reactome: -MMU-977606 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Complement Decay-Accelerating Factor - Gpi-Anchored antibodyAnti-Daf-Gpi antibodyAnti-Cd Antigen Cd55 antibodyAnti-Cd55 antibodyAnti-Cd55a antibodyAnti-Daf antibodyAnti-Daf1 antibody |
Information sourced from Uniprot.org
