• Human peripheral blood lymphocytes were stained with Anti-CD49d antibody (STJA0000906) (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.

Anti-CD49d/ITGA4 antibody [9F10] {PE/Cyanine7} (STJA0000906)

SKU:
STJA0000906

£155.50 - £420.50
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Host: Mouse
Applications: FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Integrin alpha-4 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: 9F10
Conjugation: PE/Cyanine7
Isotype: IgG1k
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: ITGA4
Gene ID: 3676
Uniprot ID: ITA4_HUMAN
Post Translational Modifications Phosphorylation on Ser-1027 inhibits PXN binding.
Function Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.
Protein Name Integrin Alpha-4
Cd49 Antigen-Like Family Member D
Integrin Alpha-Iv
Vla-4 Subunit Alpha
Cd Antigen Cd49d
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-8949275
Reactome: R-HSA-9679191
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Integrin Alpha-4 antibody
Anti-Cd49 Antigen-Like Family Member D antibody
Anti-Integrin Alpha-Iv antibody
Anti-Vla-4 Subunit Alpha antibody
Anti-Cd Antigen Cd49d antibody
Anti-ITGA4 antibody
Anti-CD49D antibody

Information sourced from Uniprot.org

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