| Tissue Specificity | Expressed in the media layer of the arterial wall (at protein level). Weakly expression in the thymus, spleen and mesenteric lymph nodes. |
| Post Translational Modifications | Phosphorylation on Ser-1028 inhibits PXN binding. |
| Function | Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. Integrin ITGA4:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction. |
| Protein Name | Integrin Alpha-4Cd49 Antigen-Like Family Member DIntegrin Alpha-IvLymphocyte Peyer Patch Adhesion Molecules Subunit AlphaLpam Subunit AlphaVla-4 Subunit AlphaCd Antigen Cd49d |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-202733Reactome: -MMU-216083 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-4 antibodyAnti-Cd49 Antigen-Like Family Member D antibodyAnti-Integrin Alpha-Iv antibodyAnti-Lymphocyte Peyer Patch Adhesion Molecules Subunit Alpha antibodyAnti-Lpam Subunit Alpha antibodyAnti-Vla-4 Subunit Alpha antibodyAnti-Cd Antigen Cd49d antibodyAnti-Itga4 antibody |
Information sourced from Uniprot.org
