| Host: |
Armenian Hamster |
| Applications: |
FC/IHC/IP |
| Reactivity: |
Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Armenian Hamster monoclonal antibody anti-CD48 antigen is suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
HM48-1 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300 |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
Store at 2-8°C. Do not freeze this product. |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenBcm1 Surface AntigenBlast-1Hm48-1Mrc Ox-45 Surface AntigenSlam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Sgp-60Cd Antigen Cd48 |
| Database Links | Reactome: R-MMU-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecreted |
| Alternative Antibody Names | Anti-Cd48 Antigen antibodyAnti-Bcm1 Surface Antigen antibodyAnti-Blast-1 antibodyAnti-Hm48-1 antibodyAnti-Mrc Ox-45 Surface Antigen antibodyAnti-Slam Family Member 2 antibodyAnti-Slamf2 antibodyAnti-Signaling Lymphocytic Activation Molecule 2 antibodyAnti-Sgp-60 antibodyAnti-Cd Antigen Cd48 antibodyAnti-Cd48 antibodyAnti-Bcm-1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![C57BL/6 murine splenocytes were stained with Anti-CD48 antibody (STJA0000222) [Used at 0.2 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/145075/291741/STJA0000222_1__29031.1631205524.jpg?c=1 "C57BL/6 murine splenocytes were stained with Anti-CD48 antibody (STJA0000222) [Used at 0.2 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.")