| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenB-Lymphocyte Activation Marker Blast-1Bcm1 Surface AntigenLeukocyte Antigen Mem-102Slam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Tct.1Cd Antigen Cd48 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Antibody Names | Anti-Cd48 Antigen antibodyAnti-B-Lymphocyte Activation Marker Blast-1 antibodyAnti-Bcm1 Surface Antigen antibodyAnti-Leukocyte Antigen Mem-102 antibodyAnti-Slam Family Member 2 antibodyAnti-Slamf2 antibodyAnti-Signaling Lymphocytic Activation Molecule 2 antibodyAnti-Tct.1 antibodyAnti-Cd Antigen Cd48 antibodyAnti-CD48 antibodyAnti-BCM1 antibodyAnti-BLAST1 antibody |
Information sourced from Uniprot.org
![Anti-CD48 antibody [156-4H9] {FITC} (STJA0002659)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/148443/293043/STJA0002659_1__13955.1631207115.jpg?c=1 "Anti-CD48 antibody [156-4H9] {FITC} (STJA0002659)")