Anti-CD46 antibody [197-2B1] (STJ16101879)

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STJ16101879

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Host: Mouse
Applications: FC/IF/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD46 is suitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 197-2B1
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunofluorescence (0, 5-1, 0 µg/ml). Immunohistology (1-2 µg/ml for 30 min at RT; an appropriate antigen retrieval method for staining of formalin-fixed tissues has not been established to date
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol: CD46
Gene ID: 4179
Uniprot ID: MCP_HUMAN
Immunogen: A BALB/c mouse was immunized with stimulated human leucocytes. Fusion partner: NS-1.
Post Translational Modifications N-glycosylated on Asn-83.Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding. Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding. In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae.which promotes infectivity. In T-cells, these isoforms may be phosphorylated by LCK.
Function Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. (Microbial infection) Acts as a receptor for cultured Measles virus. (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes.
Protein Name Membrane Cofactor Protein
Tlx
Trophoblast Leukocyte Common Antigen
Cd Antigen Cd46
Database Links Reactome: R-HSA-977606
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Acrosome Inner Membrane
Single-Pass Type I Membrane Protein
Inner Acrosomal Membrane Of Spermatozoa
Internalized Upon Binding Of Measles Virus
Herpesvirus 6 Or Neisseria Gonorrhoeae
Which Results In An Increased Susceptibility Of Infected Cells To Complement-Mediated Injury
In Cancer Cells Or Cells Infected By Neisseria
Shedding Leads To A Soluble Peptide
Alternative Antibody Names Anti-Membrane Cofactor Protein antibody
Anti-Tlx antibody
Anti-Trophoblast Leukocyte Common Antigen antibody
Anti-Cd Antigen Cd46 antibody
Anti-CD46 antibody
Anti-MCP antibody
Anti-MIC10 antibody

Information sourced from Uniprot.org

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