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Anti-CD45 antibody [Bra55] (STJ16101108)

Anti-CD45 antibody [Bra55] (STJ16101108)

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STJ16101108

£274.50 - £1,323.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	ELISA/FC/WB/IF/IHC
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-CD45 is suitable for use in ELISA, Flow Cytometry, Western Blot, Immunofluorescence and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	Bra55
Conjugation:	Unconjugated
Isotype:	IgG1k
Formulation:	PBS with 0.02% Sodium Azide.
Purification:	Affinity purified from tissue culture.
Concentration:	Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range:	ELISA (solid phase: not known; tracer: 0, 001-100 µg/ml for 30 min at RT). Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunoblotting (0, 5-1, 0 µg/ml). Immunofluorescence (0, 5-1, 0 µg/ml). Immunohistology (formalin-fixed: 2-4 µg/ml for
Storage Instruction:	Store for up to 1 year at 2-8°C upon receipt.

Gene Symbol:	PTPRC
Gene ID:	5788
Uniprot ID:	PTPRC_HUMAN
Immunogen:	A BALB/c mouse was immunized with cells of the non-T, non-B acute lymphoblastic leukemia cell line REH 6.

Tissue Specificity	Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.
Post Translational Modifications	Heavily N- and O-glycosylated.
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
Protein Name	Receptor-Type Tyrosine-Protein Phosphatase C Leukocyte Common Antigen L-Ca T200 Cd Antigen Cd45
Database Links	Reactome: R-HSA-202427 Reactome: R-HSA-416700 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft Colocalized With Dpp4 In Membrane Rafts
Alternative Antibody Names	Anti-Receptor-Type Tyrosine-Protein Phosphatase C antibody Anti-Leukocyte Common Antigen antibody Anti-L-Ca antibody Anti-T200 antibody Anti-Cd Antigen Cd45 antibody Anti-PTPRC antibody Anti-CD45 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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