| Host: |
Rabbit |
| Applications: |
IHC-P/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
IHC-P:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
GP1BA |
| Gene ID: |
2811 |
| Uniprot ID: |
GP1BA_HUMAN |
| Immunogen Region: |
15-531 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 15-531 of human CD42b (NP_000164.5). |
| Immunogen Sequence: |
HPHPICEVSKVASHLEVNCD KRNLTALPPDLPKDTTILHL SENLLYTFSLATLMPYTRLT QLNLDRCELTKLQVDGTLPV LGTLDLSHNQLQSLPLLGQT LPALTVLDVSFNRLTSLPLG ALRGLGELQELYLKGNELKT LPPGLLTPTPKLEKLSLANN NLTELPAGLLNGLENLDTLL LQENSLYTIPKGFFGSHLLP FAFLHGNPWLCNCEILYFRR WLQDNAENVYVWKQGVDVK |
| Post Translational Modifications | Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein. |
| Function | GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. |
| Protein Name | Platelet Glycoprotein Ib Alpha ChainGp-Ib AlphaGpib-AlphaGpibaGlycoprotein IbalphaAntigen Cd42b-AlphaCd Antigen Cd42b Cleaved Into - Glycocalicin |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-430116Reactome: R-HSA-75892Reactome: R-HSA-76009Reactome: R-HSA-8936459Reactome: R-HSA-9673221Reactome: R-HSA-9845620Reactome: R-HSA-9846298 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Platelet Glycoprotein Ib Alpha Chain antibodyAnti-Gp-Ib Alpha antibodyAnti-Gpib-Alpha antibodyAnti-Gpiba antibodyAnti-Glycoprotein Ibalpha antibodyAnti-Antigen Cd42b-Alpha antibodyAnti-Cd Antigen Cd42b Cleaved Into - Glycocalicin antibodyAnti-GP1BA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
