| Host: |
Mouse |
| Applications: |
FC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
| Short Description : |
Mouse monoclonal antibody anti-Integrin Alpha-Iib is suitable for use in Flow Cytometry research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
PT25 |
| Conjugation: |
FITC |
| Isotype: |
IgG1k |
| Formulation: |
0.01M PBS, pH 7.4, 02% BSA, 0.05% Proclin 300 |
| Purification: |
Purified |
| Concentration: |
05 mg/mL |
| Storage Instruction: |
Store at 4°C for 12 months Protect from light Do not freeze |
| Post Translational Modifications | Integrin alpha-IIb heavy chain: Cleaved by ELANE.the cleavage promotes activation of platelet fibrinogen receptor integrin alpha-IIb/beta-3. |
| Function | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
| Protein Name | Integrin Alpha-IibGpalpha IibGpiibPlatelet Membrane Glycoprotein IibCd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-216083Reactome: R-HSA-3000178Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-445144Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8936459Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-Iib antibodyAnti-Gpalpha Iib antibodyAnti-Gpiib antibodyAnti-Platelet Membrane Glycoprotein Iib antibodyAnti-Cd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2 antibodyAnti-ITGA2B antibodyAnti-GP2B antibodyAnti-ITGAB antibody |
Information sourced from Uniprot.org
