| Post Translational Modifications | Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. Phosphorylated by PKC.phosphorylation plays an important role for CD4 internalization. |
| Function | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. |
| Protein Name | T-Cell Surface Glycoprotein Cd4T-Cell Surface Antigen T4/Leu-3W3/25 AntigenCd Antigen Cd4 |
| Database Links | Reactome: R-RNO-1462054Reactome: -RNO-202424Reactome: -RNO-202427Reactome: -RNO-202430Reactome: -RNO-202433Reactome: -RNO-389948Reactome: -RNO-449836Reactome: -RNO-8856825Reactome: -RNO-8856828 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLocalizes To Lipid Rafts |
| Alternative Antibody Names | Anti-T-Cell Surface Glycoprotein Cd4 antibodyAnti-T-Cell Surface Antigen T4/Leu-3 antibodyAnti-W3/25 Antigen antibodyAnti-Cd Antigen Cd4 antibodyAnti-Cd4 antibody |
Information sourced from Uniprot.org
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![Rat splenocytes were stained with Anti-Rat CD4 (domain 1 Conjugated) Monoclonal Antibody (PerCP Conjugated)[Used at 0.1 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained splenocytes (empty black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/145465/292124/STJA0000612_1__46051.1631205955.jpg?c=1 "Rat splenocytes were stained with Anti-Rat CD4 (domain 1 Conjugated) Monoclonal Antibody (PerCP Conjugated)[Used at 0.1 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained splenocytes (empty black histogram) were used as control.")
