| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CD3EAP (1-170) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POLR1G |
| Gene ID: |
10849 |
| Uniprot ID: |
RPA34_HUMAN |
| Immunogen Region: |
1-170 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human CD3EAP (NP_036231.1). |
| Immunogen Sequence: |
MEEPQAGDAARFSCPPNFTA KPPASESPRFSLEALTGPDT ELWLIQAPADFAPECFNGRH VPLSGSQIVKGKLAGKRHRY RVLSSCPQAGEATLLAPSTE AGGGLTCASAPQGTLRILEG PQQSLSGSPLQPIPASPPPQ IPPGLRPRFCAFGGNPPVTG PRSALAPNLL |
| Post Translational Modifications | Isoform 2 undergoes tyrosine phosphorylation upon T-cell receptor (TCR) stimulation. This phosphorylation has not been confirmed by other groups. Isoform 1 is phosphorylated on tyrosine residues in initiation-competent Pol I-beta complexes but not in Pol I-alpha complexes. |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex. |
| Protein Name | Dna-Directed Rna Polymerase I Subunit Rpa34A34.5Antisense To Ercc-1 ProteinAse-1Cd3-Epsilon-Associated ProteinCd3e-Associated ProteinDna-Directed Rna Polymerase I Subunit GRna Polymerase I-Associated Factor Paf49 |
| Database Links | Reactome: R-HSA-427413Reactome: R-HSA-5250924Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73863 |
| Cellular Localisation | NucleusNucleolusChromosomeFound At The Fibrillar Centers Of The Nucleolus In Interphase And During Cell Division It Is Localized To The Nucleolus Organizer Regions Of The Chromosomes |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerase I Subunit Rpa34 antibodyAnti-A34.5 antibodyAnti-Antisense To Ercc-1 Protein antibodyAnti-Ase-1 antibodyAnti-Cd3-Epsilon-Associated Protein antibodyAnti-Cd3e-Associated Protein antibodyAnti-Dna-Directed Rna Polymerase I Subunit G antibodyAnti-Rna Polymerase I-Associated Factor Paf49 antibodyAnti-POLR1G antibodyAnti-ASE1 antibodyAnti-CAST antibodyAnti-CD3EAP antibodyAnti-PAF49 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
