| Post Translational Modifications | Isoform 2: Undergoes tyrosine phosphorylation upon T-cell receptor (TCR) stimulation. This phosphorylation has not been confirmed by other groups. Isoform 1: Phosphorylated on tyrosine residues in initiation-competent Pol I-beta complexes but not in Pol I-alpha complexes. |
| Function | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. Isoform 2: Has been described as a component of preformed T-cell receptor (TCR) complex. |
| Protein Name | Dna-Directed Rna Polymerase I Subunit Rpa34A34.5Antisense To Ercc-1 ProteinAse-1Cd3-Epsilon-Associated ProteinCd3e-Associated ProteinDna-Directed Rna Polymerase I Subunit GRna Polymerase I-Associated Factor Paf49 |
| Database Links | Reactome: R-HSA-427413Reactome: R-HSA-5250924Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73863 |
| Cellular Localisation | NucleusNucleolusChromosomeFound At The Fibrillar Centers Of The Nucleolus In Interphase And During Cell Division It Is Localized To The Nucleolus Organizer Regions Of The Chromosomes |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerase I Subunit Rpa34 antibodyAnti-A34.5 antibodyAnti-Antisense To Ercc-1 Protein antibodyAnti-Ase-1 antibodyAnti-Cd3-Epsilon-Associated Protein antibodyAnti-Cd3e-Associated Protein antibodyAnti-Dna-Directed Rna Polymerase I Subunit G antibodyAnti-Rna Polymerase I-Associated Factor Paf49 antibodyAnti-POLR1G antibodyAnti-ASE1 antibodyAnti-CAST antibodyAnti-CD3EAP antibodyAnti-PAF49 antibody |
Information sourced from Uniprot.org
