Function | Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. |
Protein Name | Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 12'-Phospho-Adp-Ribosyl Cyclase2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase2'-Phospho-Cyclic-Adp-Ribose TransferaseAdp-Ribosyl Cyclase 1Adprc 1Cyclic Adp-Ribose Hydrolase 1Cadpr Hydrolase 1T10Cd Antigen Cd38 |
Database Links | Reactome: R-HSA-196807 |
Cellular Localisation | Cell SurfaceMembraneSingle-Pass Type Ii Membrane Protein |
Alternative Nanobody Names | Anti-Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 nanobodyAnti-2'-Phospho-Adp-Ribosyl Cyclase nanobodyAnti-2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase nanobodyAnti-2'-Phospho-Cyclic-Adp-Ribose Transferase nanobodyAnti-Adp-Ribosyl Cyclase 1 nanobodyAnti-Adprc 1 nanobodyAnti-Cyclic Adp-Ribose Hydrolase 1 nanobodyAnti-Cadpr Hydrolase 1 nanobodyAnti-T10 nanobodyAnti-Cd Antigen Cd38 nanobodyAnti-CD38 nanobody |
Information sourced from Uniprot.org