Anti-CD37 antibody [IPO-24] {PE/EF594} (STJA0016358)

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STJA0016358

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Host: Mouse
Applications: FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Leukocyte antigen Cd37 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: IPO-24
Conjugation: PE/EF594
Isotype: IgG2bk
Formulation: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Purification: Affinity purified
Concentration: 5 Mu L/Test
Storage Instruction: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Gene Symbol: CD37
Gene ID: 951
Uniprot ID: CD37_HUMAN
Tissue Specificity B-lymphocytes. Antigen presenting cells.
Post Translational Modifications Tyrosine phosphorylated.leading to activation of downstream signaling pathways.
Function Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. Plays also a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion. Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling. Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6.
Protein Name Leukocyte Antigen Cd37
Tetraspanin-26
Tspan-26
Cd Antigen Cd37
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Leukocyte Antigen Cd37 antibody
Anti-Tetraspanin-26 antibody
Anti-Tspan-26 antibody
Anti-Cd Antigen Cd37 antibody
Anti-CD37 antibody
Anti-TSPAN26 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance