Anti-CD368/CLEC4D antibody [9B9] (STJA0027280)

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STJA0027280
£254.50 - £378.50
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Host: Mouse
Applications: FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-C-Type Lectin Domain Family 4 Member D is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : 9B9
Conjugation: Unconjugated
Isotype: IgG2bk
Formulation: 0.01M PBS, pH 7.4.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1 mg/ml
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: CLEC4D
Gene ID: 338339
Uniprot ID: CLC4D_HUMAN
Function Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells. Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells.
Protein Name C-Type Lectin Domain Family 4 Member D
C-Type Lectin Superfamily Member 8
C-Type Lectin-Like Receptor 6
Clec-6
Dendritic Cell-Associated C-Type Lectin 3
Dc-Associated C-Type Lectin 3
Dectin-3
Cd Antigen Cd368
Database Links Reactome: R-HSA-5621480
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-C-Type Lectin Domain Family 4 Member D antibody
Anti-C-Type Lectin Superfamily Member 8 antibody
Anti-C-Type Lectin-Like Receptor 6 antibody
Anti-Clec-6 antibody
Anti-Dendritic Cell-Associated C-Type Lectin 3 antibody
Anti-Dc-Associated C-Type Lectin 3 antibody
Anti-Dectin-3 antibody
Anti-Cd Antigen Cd368 antibody
Anti-CLEC4D antibody
Anti-CLECSF8 antibody
Anti-MCL antibody

Information sourced from Uniprot.org