Anti-CD337/NKp30 Neutralizing nanobody [VHH1] (STJN000630)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Natural Cytotoxicity Triggering Receptor 3 is suitable for use in ELISA and Universal research applications. |
| Applications | ELISA/Neut |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | VHH1 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | NCR3 |
| Gene ID | 259197 |
| Uniprot ID | NCTR3_HUMAN |
Additional Info
| Function | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
| Protein Name | Natural Cytotoxicity Triggering Receptor 3Activating Natural Killer Receptor P30Natural Killer Cell P30-Related ProteinNk-P30Nkp30Cd Antigen Cd337 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Nanobody Names | Anti-Natural Cytotoxicity Triggering Receptor 3 nanobodyAnti-Activating Natural Killer Receptor P30 nanobodyAnti-Natural Killer Cell P30-Related Protein nanobodyAnti-Nk-P30 nanobodyAnti-Nkp30 nanobodyAnti-Cd Antigen Cd337 nanobodyAnti-NCR3 nanobodyAnti-1C7 nanobodyAnti-LY117 nanobody |
Information sourced from Uniprot.org