| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Low affinity immunoglobulin gamma Fc region receptor II-b is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | IV-3 |
| Conjugation: | AF488 |
| Isotype: | IgG2bk |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Concentration: | 5 Mu L/Test |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | FCGR2B |
| Gene ID: | 2213 |
| Uniprot ID: | FCG2B_HUMAN |
| Tissue Specificity | Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. |
| Post Translational Modifications | Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. |
| Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B Igg Fc Receptor Ii-B Cdw32 Fc-Gamma Rii-B Fc-Gamma-Riib Fcrii-B Cd Antigen Cd32 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B antibody Anti-Igg Fc Receptor Ii-B antibody Anti-Cdw32 antibody Anti-Fc-Gamma Rii-B antibody Anti-Fc-Gamma-Riib antibody Anti-Fcrii-B antibody Anti-Cd Antigen Cd32 antibody Anti-FCGR2B antibody Anti-CD32 antibody Anti-FCG2 antibody Anti-IGFR2 antibody |
Information sourced from Uniprot.org
