Anti-CD32 antibody [SRM13515] (STJ11108245)

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STJ11108245
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Host: Rabbit
Applications: IHC-P/FC/ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : SRM13515
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: IHC-P, 1:50-1:200
FC, 1:500-1:1000
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Fcgr2
Gene ID: 14130
Uniprot ID: FCGR2_MOUSE
Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Immunogen Sequence: Mouse
Post Translational Modifications Glycosylated. When coaggregated to BCR, isoform IIB1 and isoform IIB1' become tyrosine phosphorylated and bind to the SH2 domains of the protein tyrosine phosphatase PTPC1. Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.
Function Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively.
Protein Name Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii
Fc Gamma Receptor Iib
Fc-Gamma Rii
Fc-Gamma-Riib
Fcrii
Igg Fc Receptor Ii Beta
Lymphocyte Antigen 17
Ly-17
Cd Antigen Cd32
Database Links Reactome: R-MMU-198933
Reactome: -MMU-2029481
Reactome: -MMU-2029482
Reactome: -MMU-2029485
Reactome: -MMU-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform Iib1: Cytoplasm
Cytoskeleton
Binds The Cytoskeleton And Is Not Localized In Endocytotic Pits
Isoform Iib3: Secreted
Released As A Soluble Molecule
Alternative Antibody Names Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii antibody
Anti-Fc Gamma Receptor Iib antibody
Anti-Fc-Gamma Rii antibody
Anti-Fc-Gamma-Riib antibody
Anti-Fcrii antibody
Anti-Igg Fc Receptor Ii Beta antibody
Anti-Lymphocyte Antigen 17 antibody
Anti-Ly-17 antibody
Anti-Cd Antigen Cd32 antibody
Anti-Fcgr2 antibody
Anti-Fcgr2b antibody
Anti-Ly-17 antibody

Information sourced from Uniprot.org

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