Anti-CD305/LAIR1 antibody [LA-94] (STJA0027236)

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STJA0027236
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Host: Mouse
Applications: FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : LA-94
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1 mg/ml
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: LAIR1
Gene ID: 3903
Uniprot ID: LAIR1_HUMAN
Post Translational Modifications Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK. N-glycosylated.
Function Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Protein Name Leukocyte-Associated Immunoglobulin-Like Receptor 1
Lair-1
Hlair1
Cd Antigen Cd305
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 antibody
Anti-Lair-1 antibody
Anti-Hlair1 antibody
Anti-Cd Antigen Cd305 antibody
Anti-LAIR1 antibody
Anti-CD305 antibody

Information sourced from Uniprot.org