| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
Nrp1 |
| Gene ID: |
18186 |
| Uniprot ID: |
NRP1_MOUSE |
| Immunogen Region: |
22-856 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-856 of mouse CD304 (NP_032763.2). |
| Immunogen Sequence: |
FRSDKCGGTIKIENPGYLTS PGYPHSYHPSEKCEWLIQAP EPYQRIMINFNPHFDLEDRD CKYDYVEVIDGENEGGRLWG KFCGKIAPSPVVSSGPFLFI KFVSDYETHGAGFSIRYEIF KRGPECSQNYTAPTGVIKSP GFPEKYPNSLECTYIIFAPK MSEIILEFESFDLEQDSNPP GGMFCRYDRLEIWDGFPEVG PHIGRYCGQKTPGRIRSSSG VLSMVFYTDSAIAKEGFSA |
| Tissue Specificity | Nervous system. |
| Function | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR. |
| Protein Name | Neuropilin-1A5 ProteinCd Antigen Cd304 |
| Database Links | Reactome: R-MMU-194306Reactome: -MMU-399954Reactome: -MMU-399955Reactome: -MMU-399956Reactome: -MMU-445144 |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Type I Membrane ProteinCell MembraneCytoplasm |
| Alternative Antibody Names | Anti-Neuropilin-1 antibodyAnti-A5 Protein antibodyAnti-Cd Antigen Cd304 antibodyAnti-Nrp1 antibodyAnti-Nrp antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
