| Tissue Specificity | Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. |
| Post Translational Modifications | Phosphorylated on tyrosine. N-glycosylated. |
| Function | Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. |
| Protein Name | Cmrf35-Like Molecule 8Clm-8Cd300 Antigen-Like Family Member ACmrf-35-H9Cmrf35-H9Cmrf35-HIrc1/Irc2Immunoglobulin Superfamily Member 12Igsf12Inhibitory Receptor Protein 60Irp60Nk Inhibitory ReceptorCd Antigen Cd300a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cmrf35-Like Molecule 8 antibodyAnti-Clm-8 antibodyAnti-Cd300 Antigen-Like Family Member A antibodyAnti-Cmrf-35-H9 antibodyAnti-Cmrf35-H9 antibodyAnti-Cmrf35-H antibodyAnti-Irc1/Irc2 antibodyAnti-Immunoglobulin Superfamily Member 12 antibodyAnti-Igsf12 antibodyAnti-Inhibitory Receptor Protein 60 antibodyAnti-Irp60 antibodyAnti-Nk Inhibitory Receptor antibodyAnti-Cd Antigen Cd300a antibodyAnti-CD300A antibodyAnti-CMRF35H antibodyAnti-IGSF12 antibodyAnti-HSPC083 antibody |
Information sourced from Uniprot.org
