| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNFRSF8 |
| Gene ID: | 943 |
| Uniprot ID: | TNR8_HUMAN |
| Immunogen Region: | 496-595 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 496-595 of human CD30 (P28908). |
| Immunogen Sequence: | SPRDLPEPRVSTEHTNNKIE KIYIMKADTVIVGTVKAELP EGRGLAGPAEPELEEELEAD HTPHYPEQETEPPLGSCSDV MLSVEEEGKEDPLPTAASGK |
| Tissue Specificity | Isoform 2: Detected in alveolar macrophages (at protein level). |
| Post Translational Modifications | Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated. |
| Function | Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 8Cd30l ReceptorKi-1 AntigenLymphocyte Activation Antigen Cd30Cd Antigen Cd30 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 8 antibodyAnti-Cd30l Receptor antibodyAnti-Ki-1 Antigen antibodyAnti-Lymphocyte Activation Antigen Cd30 antibodyAnti-Cd Antigen Cd30 antibodyAnti-TNFRSF8 antibodyAnti-CD30 antibodyAnti-D1S166E antibody |
Information sourced from Uniprot.org