Anti-CD3 Epsilon antibody [145-2C11] {PE/Cyanine5} (STJA0001666)

SKU:
STJA0001666

£130.50 - £195.50
Current Stock:
Host: Armenian Hamster
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Armenian Hamster monoclonal antibody anti-T-cell surface glycoprotein CD3 epsilon chain is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: 145-2C11
Conjugation: PE/Cyanine5
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 1% BSA
Concentration: 0.2 mg/mL
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Cd3e
Gene ID: 12501
Uniprot ID: CD3E_MOUSE
Post Translational Modifications Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
Function Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
Protein Name T-Cell Surface Glycoprotein Cd3 Epsilon Chain
T-Cell Surface Antigen T3/Leu-4 Epsilon Chain
Cd Antigen Cd3e
Database Links Reactome: R-MMU-198933
Reactome: -MMU-202424
Reactome: -MMU-202427
Reactome: -MMU-202430
Reactome: -MMU-202433
Reactome: -MMU-389948
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-T-Cell Surface Glycoprotein Cd3 Epsilon Chain antibody
Anti-T-Cell Surface Antigen T3/Leu-4 Epsilon Chain antibody
Anti-Cd Antigen Cd3e antibody
Anti-Cd3e antibody

Information sourced from Uniprot.org

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