Anti-CD3/CD4/CD8a antibody [OKT3, RPA-T4, OKT8] {APC/FITC/PerCP-Cyanine5.5} (STJA0002510)
SPECIFICATIONS
ClonalityMonoclonal
ConjugationAPC/FITC/PerCP-Cyanine5.5
General Information
| Short Description | NA monoclonal anti-CD3-APC/CD4-FITC/CD8 Alpha-PerCP-CyanIne5.5 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | OKT3, RPA-T4, OKT8 |
| Conjugation | APC/FITC/PerCP-Cyanine5.5 |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
Additional Info
| Background | This product is a FC antibody cocktail made up of APC Anti-Human CD3 Antibody [Clone: OKT3] (Mouse IgG2a, k) , FITC Anti-Human CD4 Antibody [Clone: RPA-T4] (Mouse IgG1, k) and PE/Cyanine5.5 Anti-Human CD8a Antibody [Clone: OKT-8] (Mouse IgG2a, k). CD3 is a heterotetrameric protein consisting of a CD3 Gamma, a CD Delta and 2 CD3 Epsilon. It forms complex with TCR. OKT-3 recognize human CD3 Epsilon. Human CD3 is expressed on the surface of T cells and NKT cells. CD4 is also called Leu-3 or T4. It s a single-chain type I transmembrane glycoprotein, mainly expressed on the surface of T cells, and monocytes/macrophages. In T cells, CD4 forms complex with TCR/CD3 and play important roles in T cell immunity. The target of HIV is CD4+ T cells. Reduction of CD4+ T cells is the main reason of defected immunity after HIV infection. CD8 is mainly expressed on cytotoxic T cells and also some subpopulations of NK cells. CD8 forms dimer function. In most cells, CD8 is a heterodimer consisting of CD8a and CD8b, but in NK cells nearly all CD8 is homodimer of CD8a. CD8a can form co-receptor with MHC-I restricted TCR to promote T cell antigen recognition and activation. |
Information sourced from Uniprot.org