Anti-CD294/PTGDR2 antibody [SAA0325] (STJA0027531)

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STJA0027531-100
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Short Description :Mouse monoclonal Prostaglandin D2 Receptor 2 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SAA0325
Isotype:IgG2ak
Conjugation:Unconjugated
Concentration:1 mg/ml
Purification:Protein A/G purified from cell culture supernatant.
Formulation:0.01M PBS, pH 7.4, 0.09% Sodium azide.
Storage Instruction:Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol:PTGDR2
Gene ID:11251
Uniprot ID:PD2R2_HUMAN
Post Translational Modifications Phosphorylated.
Function Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Protein Name Prostaglandin D2 Receptor 2
Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells
G-Protein Coupled Receptor 44
Cd Antigen Cd294
Database Links Reactome: R-HSA-391908
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Internalized Receptors Colocalized With Rab11a
Alternative Antibody Names Anti-Prostaglandin D2 Receptor 2 antibody
Anti-Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells antibody
Anti-G-Protein Coupled Receptor 44 antibody
Anti-Cd Antigen Cd294 antibody
Anti-PTGDR2 antibody
Anti-CRTH2 antibody
Anti-DL1R antibody
Anti-GPR44 antibody

Information sourced from Uniprot.org

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