| Post Translational Modifications | Phosphorylated. |
| Function | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. |
| Protein Name | Prostaglandin D2 Receptor 2Chemoattractant Receptor-Homologous Molecule Expressed On Th2 CellsG-Protein Coupled Receptor 44Cd Antigen Cd294 |
| Database Links | Reactome: R-HSA-391908Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalized Receptors Colocalized With Rab11a |
| Alternative Antibody Names | Anti-Prostaglandin D2 Receptor 2 antibodyAnti-Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells antibodyAnti-G-Protein Coupled Receptor 44 antibodyAnti-Cd Antigen Cd294 antibodyAnti-PTGDR2 antibodyAnti-CRTH2 antibodyAnti-DL1R antibodyAnti-GPR44 antibody |
Information sourced from Uniprot.org
