Anti-CD294/PTGDR2 antibody [SAA0325] {APC} (STJA0029733)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationAPC
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal Prostaglandin D2 Receptor 2 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0325 |
| Isotype | IgG2ak |
| Conjugation | APC |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | PTGDR2 |
| Gene ID | 11251 |
| Uniprot ID | PD2R2_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated. |
| Function | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. |
| Protein Name | Prostaglandin D2 Receptor 2Chemoattractant Receptor-Homologous Molecule Expressed On Th2 CellsG-Protein Coupled Receptor 44Cd Antigen Cd294 |
| Database Links | Reactome: R-HSA-391908Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalized Receptors Colocalized With Rab11a |
| Alternative Antibody Names | Anti-Prostaglandin D2 Receptor 2 antibodyAnti-Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells antibodyAnti-G-Protein Coupled Receptor 44 antibodyAnti-Cd Antigen Cd294 antibodyAnti-PTGDR2 antibodyAnti-CRTH2 antibodyAnti-DL1R antibodyAnti-GPR44 antibody |
Information sourced from Uniprot.org