| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000 |
| Gene Symbol: |
Ptgdr2 |
| Gene ID: |
14764 |
| Uniprot ID: |
PD2R2_MOUSE |
| Immunogen Region: |
1-32 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-32 of mouse CD294 (NP_034092.1). |
| Immunogen Sequence: |
MANVTLKPLCPLLEEMVQLP NHSNSSLRYIDH |
| Post Translational Modifications | Phosphorylated. |
| Function | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. |
| Protein Name | Prostaglandin D2 Receptor 2Chemoattractant Receptor-Homologous Molecule Expressed On Th2 CellsG-Protein Coupled Receptor 44Cd Antigen Cd294 |
| Database Links | Reactome: R-MMU-391908Reactome: -MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalized Receptors Colocalized With Rab11a |
| Alternative Antibody Names | Anti-Prostaglandin D2 Receptor 2 antibodyAnti-Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells antibodyAnti-G-Protein Coupled Receptor 44 antibodyAnti-Cd Antigen Cd294 antibodyAnti-Ptgdr2 antibodyAnti-Crth2 antibodyAnti-Gpr44 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
