| Function | Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. |
| Protein Name | T-Cell-Specific Surface Glycoprotein Cd28Cd Antigen Cd28 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-389356Reactome: -MMU-389357Reactome: -MMU-389359Reactome: -MMU-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Cell-Specific Surface Glycoprotein Cd28 antibodyAnti-Cd Antigen Cd28 antibodyAnti-Cd28 antibody |
Information sourced from Uniprot.org
![C57BL/6 murine splenocytes were stained with Anti-Mouse CD28 Monoclonal Antibody (AF647 Conjuaged)[Used at 0.2 µg/10<sup>6</sup> cells dilution] and Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated). Splenocytes stained with Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated) (right) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/145129/291795/STJA0000276_1__56941.1631205595.jpg?c=1 "C57BL/6 murine splenocytes were stained with Anti-Mouse CD28 Monoclonal Antibody (AF647 Conjuaged)[Used at 0.2 µg/10<sup>6</sup> cells dilution] and Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated). Splenocytes stained with Anti-Mouse CD3 Monoclonal Antibody (AF488 Conjugated) (right) were used as control.")