| Host: | Hamster |
| Applications: | FC/IHC/IP |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Hamster monoclonal antibody anti-T-cell-specific surface glycoprotein CD28 is suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 37.51 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300 |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at 2-8°C. Do not freeze this product. |
| Gene Symbol: | Cd28 |
| Gene ID: | 12487 |
| Uniprot ID: | CD28_MOUSE |
| Post Translational Modifications | Phosphorylated by LCK. Dephosphorylated by PTPN11. |
| Function | Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. |
| Protein Name | T-Cell-Specific Surface Glycoprotein Cd28 Cd Antigen Cd28 |
| Database Links | Reactome: R-MMU-1257604 Reactome: -MMU-389356 Reactome: -MMU-389357 Reactome: -MMU-389359 Reactome: -MMU-6811558 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Cell-Specific Surface Glycoprotein Cd28 antibody Anti-Cd Antigen Cd28 antibody Anti-Cd28 antibody |
Information sourced from Uniprot.org