Anti-CD276 antibody (271-320 aa) (STJ96650)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD276 at the amino acid range 271-320
General Information
| Short Description | Rabbit polyclonal anti-CD276 antigen (271-320 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CD276 |
| Gene ID | 80381 |
| Uniprot ID | CD276_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human CD276 at the amino acid range 271-320 |
| Immunogen Region | 271-320 aa |
| Specificity | CD276 Polyclonal Antibody detects endogenous levels of CD276 protein. |
Additional Info
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Protein Name | Cd276 Antigen4ig-B7-H3B7 Homolog 3B7-H3Costimulatory MoleculeCd Antigen Cd276 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cd276 Antigen antibodyAnti-4ig-B7-H3 antibodyAnti-B7 Homolog 3 antibodyAnti-B7-H3 antibodyAnti-Costimulatory Molecule antibodyAnti-Cd Antigen Cd276 antibodyAnti-CD276 antibodyAnti-B7H3 antibodyAnti-PSEC0249 antibodyAnti-UNQ309 antibodyAnti-PRO352 antibody |
Information sourced from Uniprot.org