Anti-CD275/ICOSLG nanobody [SAA1282] (STJN000049)

Anti-CD275/ICOSLG nanobody [SAA1282] (STJN000049)

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STJN000049
£378.50 - £1,632.50
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Covered by St John's Laboratory Guarantee

Host: Alpaca
Applications: ELISA/FC/SPR
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Icos Ligand is suitable for use in ELISA, Flow Cytometry and SPR research applications.
Clonality : Monoclonal
Clone ID : SAA1282
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: ICOSLG
Gene ID: 23308
Uniprot ID: ICOSL_HUMAN
Function Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP).
Protein Name Icos Ligand
B7 Homolog 2
B7-H2
B7-Like Protein Gl50
B7-Related Protein 1
B7rp-1
Cd Antigen Cd275
Database Links Reactome: R-HSA-388841
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cell Membrane
Alternative Nanobody Names Anti-Icos Ligand nanobody
Anti-B7 Homolog 2 nanobody
Anti-B7-H2 nanobody
Anti-B7-Like Protein Gl50 nanobody
Anti-B7-Related Protein 1 nanobody
Anti-B7rp-1 nanobody
Anti-Cd Antigen Cd275 nanobody
Anti-ICOSLG nanobody
Anti-B7H2 nanobody
Anti-B7RP1 nanobody
Anti-ICOSL nanobody
Anti-KIAA0653 nanobody

Information sourced from Uniprot.org

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