Anti-CD272 antibody [PK18.6] {PE} (STJA0004107)

SKU:
STJA0004107

£141.50 - £245.50
Current Stock:
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-B-And T-Lymphocyte Attenuator
Clonality: Monoclonal
Clone ID: PK18.6
Conjugation: PE
Isotype: IgG1k
Formulation: PBS with 0.05% Proclin300, 1% BSA
Concentration: 0.2 mg/mL
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Btla
Gene ID: 208154
Uniprot ID: BTLA_MOUSE
Tissue Specificity Expressed in splenic T- and B-cells as well as lymph node tissues but very weakly in somatic tissues. Also expressed in macrophages, NK cells and dendritic cells. A polymorphic tissue distribution between several strains is seen.
Post Translational Modifications Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated.
Function Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Protein Name B- And T-Lymphocyte Attenuator
B- And T-Lymphocyte-Associated Protein
Cd Antigen Cd272
Database Links Reactome: R-MMU-388841
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-B- And T-Lymphocyte Attenuator antibody
Anti-B- And T-Lymphocyte-Associated Protein antibody
Anti-Cd Antigen Cd272 antibody
Anti-Btla antibody

Information sourced from Uniprot.org

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