Anti-CD270/TNFRSF14 antibody [36H12] {PE} (STJA0031580)

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STJA0031580
£310.50 - £472.50
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Host: Mouse
Applications: FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Tumor Necrosis Factor Receptor Superfamily Member 14 is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : 36H12
Conjugation: PE
Isotype: IgG1k
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: TNFRSF14
Gene ID: 8764
Uniprot ID: TNR14_HUMAN
Post Translational Modifications N-glycosylated.
Function Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response. In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines. Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. May interact in cis (on the same cell) or in trans (on other cells) with BTLA. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 14
Herpes Virus Entry Mediator A
Herpesvirus Entry Mediator A
Hvea
Tumor Necrosis Factor Receptor-Like 2
Tr2
Cd Antigen Cd270
Database Links Reactome: R-HSA-388841
Reactome: R-HSA-5669034
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Tumor Necrosis Factor Receptor Superfamily Member 14 antibody
Anti-Herpes Virus Entry Mediator A antibody
Anti-Herpesvirus Entry Mediator A antibody
Anti-Hvea antibody
Anti-Tumor Necrosis Factor Receptor-Like 2 antibody
Anti-Tr2 antibody
Anti-Cd Antigen Cd270 antibody
Anti-TNFRSF14 antibody
Anti-HVEA antibody
Anti-HVEM antibody
Anti-UNQ329 antibody
Anti-PRO509 antibody

Information sourced from Uniprot.org