| Host: |
Mouse |
| Applications: |
FC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-CD27 is suitable for use in Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
LT27 |
| Conjugation: |
PE |
| Isotype: |
IgG2a |
| Formulation: |
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Purification: |
Purified by protein-A affinity chromatography. |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
CD27 |
| Gene ID: |
939 |
| Uniprot ID: |
CD27_HUMAN |
| Immunogen: |
Human peripheral blood lymphocytes |
| Tissue Specificity | Found in most T-lymphocytes. |
| Post Translational Modifications | Phosphorylated. N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. |
| Function | Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue. |
| Protein Name | Cd27 AntigenCd27l ReceptorT-Cell Activation Antigen Cd27T14Tumor Necrosis Factor Receptor Superfamily Member 7Cd Antigen Cd27 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cd27 Antigen antibodyAnti-Cd27l Receptor antibodyAnti-T-Cell Activation Antigen Cd27 antibodyAnti-T14 antibodyAnti-Tumor Necrosis Factor Receptor Superfamily Member 7 antibodyAnti-Cd Antigen Cd27 antibodyAnti-CD27 antibodyAnti-TNFRSF7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Anti-CD27 antibody [O323] {PE} (STJA0001847)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/147631/292820/STJA0001847_1__61140.1631206801.jpg?c=1 "Anti-CD27 antibody [O323] {PE} (STJA0001847)")
