Host: |
Rabbit |
Applications: |
WB/IF/ICC/ELISA |
Reactivity: |
Human/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: |
Monoclonal |
Clone ID: |
S0MR |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: |
Affinity purification |
Concentration: |
Lot specific |
Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
CD27 |
Gene ID: |
939 |
Uniprot ID: |
CD27_HUMAN |
Immunogen Region: |
1-100 |
Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD27 (P26842). |
Immunogen Sequence: |
MARPHPWWLCVLGTLVGLSA TPAPKSCPERHYWAQGKLCC QMCEPGTFLVKDCDQHRKAA QCDPCIPGVSFSPDHHTRPH CESCRHCNSGLLVRNCTITA |
Tissue Specificity | Found in most T-lymphocytes. |
Post Translational Modifications | Phosphorylated. N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. |
Function | Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue. |
Protein Name | Cd27 AntigenCd27l ReceptorT-Cell Activation Antigen Cd27T14Tumor Necrosis Factor Receptor Superfamily Member 7Cd Antigen Cd27 |
Database Links | Reactome: R-HSA-5669034 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Cd27 Antigen antibodyAnti-Cd27l Receptor antibodyAnti-T-Cell Activation Antigen Cd27 antibodyAnti-T14 antibodyAnti-Tumor Necrosis Factor Receptor Superfamily Member 7 antibodyAnti-Cd Antigen Cd27 antibodyAnti-CD27 antibodyAnti-TNFRSF7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance