Anti-CD230/PRNP nanobody [SAA0883] (STJN000092)

Anti-CD230/PRNP nanobody [SAA0883] (STJN000092)

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STJN000092
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Major Prion Protein is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA0883
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: PRNP
Gene ID: 5621
Uniprot ID: PRIO_HUMAN
Function Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Protein Name Major Prion Protein
Prp
Ascr
Prp27-30
Prp33-35c
Cd Antigen Cd230
Database Links
Reactome: R-HSA-419037
Reactome: R-HSA-9609523
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Golgi Apparatus
Targeted To Lipid Rafts Via Association With The Heparan Sulfate Chains Of Gpc1
Colocates
In The Presence Of Cu(2+)
To Vesicles In Para- And Perinuclear Regions
Where Both Proteins Undergo Internalization
Heparin Displaces Prnp From Lipid Rafts And Promotes Endocytosis
Alternative Nanobody Names Anti-Major Prion Protein nanobody
Anti-Prp nanobody
Anti-Ascr nanobody
Anti-Prp27-30 nanobody
Anti-Prp33-35c nanobody
Anti-Cd Antigen Cd230 nanobody
Anti-PRNP nanobody
Anti-ALTPRP nanobody
Anti-PRIP nanobody
Anti-PRP nanobody

Information sourced from Uniprot.org

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